MDM4 Amplification Reference Standard
CBP40057
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| Introduction | ||
| Format | Genomic DNA | |
| Description | MDM4, MDM4 regulator of p53, is an E3 ligase (PMID: 30026328) that inhibits Tp53 activity through interaction with the transcriptional activation domain of Tp53, and regulates Tp53 degradation together with Mdm2 (PMID: 23303139). MDM4 amplification leads to overexpression of Mdm4 in many cancers, including sarcoma, retinoblastoma, breast, lung, and colon cancers, as well as melanoma (PMID: 27371671), invasive lobular breast carcinoma (PMID: 31229512), Burkitt lymphoma (PMID: 31000522), fibrolamellar hepatocellular carcinoma (PMID: 31322272), and glioblastoma multiforme (PMID: 26328271). | |
| Technical Data | ||
| Copy number | 5.99 （DdPCR） | |
| Definition | Amplification | |
| Product Information | ||
| Intended Use | Research Use Only | |
| Unit Size | 1ug | |
| Concentration | Download for COA | |
| Purity | Download for COA | |
| DNA electrophoresis | Download for COA | |
| Sanger sequencing | Download for COA | |
| Storage | 2-8℃ | |
| Expiry | 36 months from the date of manufacture | |
